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Mutation SARS-CoV-2 - strain AY.4.2

PJSC “SPC “Diaproph-Med” constantly monitors SARS-CoV-2 mutations and the emergence of new

variants of the virus in order to improve the design of test systems to ensure maximum sensitivity and


The new strain SARS-CoV-2 was identified as AY.4.2. It is a descendant of the Delta variant (B.1.167.2)

and carries two characteristic mutations in the spike protein, Y145H and A222V.

Most of the SARS-CoV-2 mutations have independently occurred many times in unrelated strains. Both

Y145H and A222V spike mutations have been found in various other variants of SARS-CoV-2 strains since

the start of the pandemic, but still remain at a low frequency. The first strains carrying both mutations

were sequenced in April 2020. These mutations are not a priori obvious candidates for increasing viral

transmissibility, but we know that mutations can have different consequences, sometimes unexpected,

in different variants of the SARS-CoV-2 virus strains.

As it was written earlier, the use of conservative domains (sections) of the SARS-CoV-2 coronavirus

antigens in the design indicates the absence of a significant threat of reducing the diagnostic sensitivity

of test systems produced by PJSC “SPC “Diaproph-Med” to detect coronavirus disease due to mutations

and the emergence of new variants of strains SARS-CoV-2, including strain AY.4.2.

There is still not enough information about the new strain and work on its study continues.

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